898 research outputs found
Practising Law in Australia in 2010
Thankyou very much for the kind invitation to talk to you briefly tonight on "Practising Law in 2010." What a broad topic – where does one start? One thing about making future predictions is when I leave here tonight you will have absolutely no idea whether I am right or wrong, and all of you will have long forgotten about what I say to be bothered hunting me down in six years time if my predictions turn out to be bunkum. A word of caution though, as a soothsayer my credentials may not be all that inviting. When clearing out some old papers recently I came across one I wrote in 1992 as a then Managing Partner for a partners' conference, and I made two bold statements to my fellow partners. Number one. I told them that the paperless office was 'just around the corner' and therefore we should spend a significant amount of dollars in updating our firm's IT infrastructure, hardware and software. The cost of doing this would be in part be offset by future paper savings!
Shining A Light On Galactic Outflows: Photo-Ionized Outflows
We study the ionization structure of galactic outflows in 37 nearby, star
forming galaxies with the Cosmic Origins Spectrograph on the Hubble Space
Telescope. We use the O I, Si II, Si III, and Si IV ultraviolet absorption
lines to characterize the different ionization states of outflowing gas. We
measure the equivalent widths, line widths, and outflow velocities of the four
transitions, and find shallow scaling relations between them and galactic
stellar mass and star formation rate. Regardless of the ionization potential,
lines of similar strength have similar velocities and line widths, indicating
that the four transitions can be modeled as a co-moving phase. The Si
equivalent width ratios (e.g. Si IV/Si II) have low dispersion, and little
variation with stellar mass; while ratios with O I and Si vary by a factor of 2
for a given stellar mass. Photo-ionization models reproduce these equivalent
width ratios, while shock models under predict the relative amount of high
ionization gas. The photo-ionization models constrain the ionization parameter
(U) between -2.25 < log(U) < -1.5, and require that the outflow metallicities
are greater than 0.5 Z. We derive ionization fractions for the
transitions, and show that the range of ionization parameters and stellar
metallicities leads to a factor of 1.15-10 variation in the ionization
fractions. Historically, mass outflow rates are calculated by converting a
column density measurement from a single metal ion into a total Hydrogen column
density using an ionization fraction, thus mass outflow rates are sensitive to
the assumed ionization structure of the outflow.Comment: 30 pages, 17 tables, 14 figures. Accepted for publication in MNRA
Hormone replacement therapy for women with type 1 diabetes mellitus
Background:
There is conflicting information about the impact of the menopause on glycaemic control amongst women with type 1 diabetes. Some menopausal women with type 1 diabetes are treated with hormone replacement therapy (HRT) but the effects of this treatment have, to date, not been established.Objectives: To assess the effects of HRT for women with type 1 diabetes mellitus.Search methods: We searched The Cochrane Library, MEDLINE, EMBASE, CINAHL and PsycINFO from their inception to June 2012. The last search was run for all databases on 18 June 2012.Selection criteria: We selected randomised controlled trials or controlled clinical trials that involved peri‐ or postmenopausal women with type 1 diabetes undergoing HRT as an intervention.Data collection and analysis: Two researchers independently applied the inclusion criteria to the identified studies and assessed risk of bias. Disagreements were resolved by discussion or by intervention by a third party. Descriptive analysis was conducted for the review.Main results: Ninety‐two publications were screened. No studies met the inclusion criteria exclusively but one study that included both type 1 and type 2 diabetes participants was considered. This randomised clinical trial (RCT) compared HRT (N = 27) with placebo (N = 29) over 12 months. The outcome measures were cardiovascular risk factors, including lipid profile, glycaemic control, blood pressure and body weight. No significant differences between placebo and HTR were detected. Patient‐important outcomes like all‐cause mortality, cardiovascular disease, diabetic complications or health‐related quality of life were not investigated.Authors' conclusions: There is a lack of evidence around the use of HRT in women with type 1 diabetes. The one study that has been undertaken in this area is underpowered. More RCTs are required in the area to examine the impact of HRT on glycaemic control and cardiovascular outcomes.https://doi.org/10.1002/14651858.CD008613.pub2pubpub
Use of electronic medical records and biomarkers to manage risk and resource efficiencies
Peer reviewedPublisher PD
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